Carbon Monoxide Releasing Pharmaceuticals
نویسندگان
چکیده
Carbon monoxide (CO) was ignored by the medical research community for decades, who thought that no biological relevance could emerge from exploring the physiological effects of a gas that had earned itself a reputation over the years as a ‘silent killer’ [2] . The well-known poisoning by carbon monoxide is a result of it binding to Hemoglobin, the oxygen carrier in blood with very high affinity. Against this dogma is the fact that every cell in a mammalian organism expresses Heme Oxygenase (HO) enzymes and thus has the potential to continuously generate CO [4] .
منابع مشابه
Mechanism(s) Involved in Carbon Monoxide-releasing Molecule-2-mediated Cardioprotection During Ischaemia-reperfusion Injury in Isolated Rat Heart
The purpose of the present study was to determine the mechanism(s) involved in carbon monoxide-releasing molecule-2, carbon monoxide-releasing molecule-2-induced cardioprotection. We used the transition metal carbonyl compound carbon monoxide-releasing molecule-2 that can act as carbon monoxide donor in cardiac ischaemia-reperfusion injury model using isolated rat heart preparation. Langendorff...
متن کاملCarbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities.
The well-known adverse effects of CO (carbon monoxide) intoxication are counterbalanced by its positive actions when small amounts are produced intracellularly by the cytoprotective enzyme HO-1 (haem oxygenase-1). As compelling scientific evidence accumulated to sustain that HO-1 plays a fundamental role in counteracting vascular and inflammatory disorders, we began to appreciate that a control...
متن کاملAuthor's response to reviews Title: Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats Authors:
متن کامل
CuAAC click functionalization of azide-modified nanodiamond with a photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)3(tpm)]+.
The copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC) was used for the first time to attach a biologically active carbon monoxide delivery agent to modified nanodiamond (ND) as a highly biocompatible carrier. The [Mn(CO)(3)(tpm)](+) photoactivatable CO-releasing molecule (PhotoCORM) on the surface retained the carbon monoxide release properties of the parent compound as shown with...
متن کامل